Then you’d need to run adb once for the first install of fdroid/shizuku. Admittedly not great, but doing that once will not stop many OSS enthousiasts. It would widen the gap between power user and normal user considerably which also isn’t great.

You do not, it can connect with your own wireless debugging session. https://shizuku.rikka.app/guide/setup/#start-via-wireless-debugging Works since android 11

At least with something like shizuku one can effectively adb to your own phone, so even if adb became required to install non-google-approved apps on one’s own phone… It will not block FOSS for long.

Wires are annoying as hell, and a proper desktop wireless headphone will have basically no loss in quality as they have a base station and are not using Bluetooth.

Same with the mouse, for things like gaming latency can be an issue, but a proper one isn’t using Bluetooth either so no issues on that end (or at least the difference is lower than my skill issue, which causes me to lose games)